Narcotics and sedatives provide patients with relief from pain and discomfort. However, doses must be selected carefully and patients monitored closely to prevent accidental overdoses and adverse drug events (ADEs). Using standardized approaches, such as pre-printed orders and protocols and verification of equipment settings, helps reduce the risk of errors that can lead to ADEs. Remember that inadequate dosing of these medications can also lead to ADEs, such as uncontrolled pain and the subsequent effects. Strategies such as using pain management teams can help clinicians manage pain and sedation effectively yet safely.